關(guān)鍵信息

    在這項(xiàng)縱向隊(duì)列研究中，研究者對(duì)421對(duì)母女進(jìn)行評(píng)估。研究發(fā)現(xiàn)，與血糖水平位于下五分位數(shù)母親生出的女兒相比，妊娠糖尿病母親生出的女兒BMI≥85th、體重身高比或體脂百分比位于上四分位數(shù)風(fēng)險(xiǎn)顯著增加（OR,2.80–3.56）。此外，該研究還發(fā)現(xiàn)，患有妊娠糖尿病，且孕前BMI水平較高的母親生出的女兒肥胖癥患病率最高。

    該研究提示，為了降低女性后代肥胖癥發(fā)生風(fēng)險(xiǎn)，需要對(duì)妊娠糖尿病進(jìn)行篩查和干預(yù)。

    TAKE-HOME MESSAGE

    The authors of this longitudinal study evaluated 421 mother–daughter pairs. Compared with daughters born to mothers who had blood glucose levels in the lowest quintile, daughters born to mothers who had gestational diabetes mellitus had increased odds of having a BMI ≥85th percentile or of being in the highest quartile for weight–height ratio or percent body fat （OR, 2.80–3.56）。 The highest rates of adiposity in daughters were seen for mothers who had gestational diabetes and high pregravid BMI.

    Screening and intervention for gestational diabetes are warranted to decrease the risk for adiposity in female offspring.

    Diabetes Care

    Maternal Hyperglycemia During Pregnancy Predicts Adiposity of the Offspring

    Diabetes Care 2014 Nov 01;37（11）2996-3002, A Kubo, A Ferrara, GC Windham, LC Greenspan, J Deardorff, RA Hiatt, CP Quesenberry, C Laurent, AS Mirabedi, LH Kushi

    From MEDLINE?/PubMed?, a database of the U.S. National Library of Medicine.

    This abstract is available on the publisher's site.

    Access this abstract now

    Copyright ? 2014 Elsevier Inc. All rights reserved.