《Hodgkin Disease》專家PPT內(nèi)容預(yù)覽
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《Hodgkin Disease》專家PPT內(nèi)容簡介
    Definition:
    neoplastic disorder with development of specific infiltrate containing pathologic Reed-Sternberg cells. It usually arises in lymph nodes and spreads to contiguous groups. Extranodal presentation are rare. Disease is associated with defective cellular immunity. 

    Incidence:
    - 2-4 cases per 100000 population / year
    - bimodal age distribution : 
    15-35 years and above 50 years
    - male predominance M:F = 1,7:1

    Clinical Presentation
    Nontender lymph nodes enlargement ( localised )
    neck and supraclavicular area 60-80%
    mediastinal adenopathy 50%
    other ( abdominal, extranodal disease )
    systemic symptoms (B symptoms) 30%
    fever 
    night sweats
    unexplained weight loss (10% per 6 months)
    other symptoms 
    fatigue, weakness, pruritus
    cough , chest pain, shortness of breath, vena cava syndrome
    abdominal pain, bowel disturbances, ascites
    bone pain

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