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The Clinical Significance of Nuclear YAP Expression in Hepatocellular Carcinoma
徐 智
南京醫(yī)科大學(xué)附屬南京第一醫(yī)院暨
南京市第一醫(yī)院    腫瘤內(nèi)科

Worldwide incidence of HCC
Blum HE, Spangenberg HC. Arch Iran Med. 2007 Jul;10(3):361-71.
Identification of Yes-associated Protein (YAP)
YAP improves cell proliferation

YAP induces anchorage-independent growth
MIHA-YAP cells but not MIHA-Vec could form colonies in soft-agar.
YAP enhances cellular mobility and invasiveness
MIHA-YAP cells gained advantages in cell migration and invasion.
IHC results of YAP in HCC
53.7% HCC samples showed nuclear YAP positive.
Clinical association of nuclear YAP in HCC

Clinical association of nuclear YAP and HCC-specific postsurgical recurrence
Kaplan-Meier
Median RFT：
Nuclear YAP negative: 25.8 months vs. Nuclear YAP positive：12.9 months
Nuclear YAP is an independent prognostic marker for HCC recurrence

Summary
YAP confers tumorigenic and metastatic potentials in hepatocytes, as evidenced by enhanced aptitudes in cell viability, anchorage-independent growth, migration and invasion.
YAP nuclear accumulation was found in the 53.7% of HCC, correlated with poorer tumor differentiation and higher serum alpha-fetoprotein (AFP) levels.
Nuclear YAP is an independent predictor for HCC-specific recurrence-free survival.
YAP plays an important role in HCC development and progression.

Acknowledgement
新加坡**大學(xué)外科系和藥學(xué)系 Asso. Prof. John M. Luk
香港大學(xué)外科系 Prof. Fan S. T.，Prof. Poon R. T.  and Surgical Tissue Bank
南京市第一醫(yī)院腫瘤內(nèi)科

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