Severe Acute Respiratory Syndrome (SARS)

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Severe Acute Respiratory Syndrome (SARS) 
Lydia Ho & Rui Yang
BISC 209
Professor Mary Allen

November 16, 02
Initial cases of SARS appeared in South China

March 03: 
New reports of outbreaks came in from Hong Kong, Singapore & Vietnam


March 24, 03: 
Scientists in CDC and HK announced isolation of new coronavirus from SARS patients

April 25, 03: 
Nearly 3000 SARS cases have been identified in China


The Pathogen behind it all…
Discovery of the new virus
Kochs postulates
Discovery of novel coronavirus in patient
Isolation of cell culture
Reproducible symptom in cell culture
Identical isolates produced

Novel coronavirus is the cause of SARS

Coronaviridae
A family of large, enveloped, positive-sense single stranded RNA virus
Irregular shape
Characteristic ‘club-shaped’ surface projections (~20nm)

SARS-CoV Genome
71% of the genome codes for polyproteins 
Remainder: codes for structural proteins
S (spike): receptor binding, cell fusion, major antigen 
E (envelop): envelop-associated protein
M (membrane): transmembrane-budding
N (nucleocapsid): genome-associated phosphoprotein
SARS-CoV Genome

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